Selected publications
Amherst College undergraduates are underlined.
Liimatta K, E Flaherty, G Ro, DK Nguyen, C Prado, and AE Purdy. 2018. A putative acetylation system in Vibrio cholerae modulates virulence in arthropod hosts. Applied Environmental Microbiology 84(21): e01113-18.
Muzhingi I, Prado C, Sylla M, Diehl FF, Nguyen DK, Servos MM, Flores Ramos S, Purdy AE. Modulation of CrbS-Dependent Activation of the Acetate Switch in Vibrio cholerae. Journal of Bacteriology 2018 Nov 6;200(23):e00380-18. doi: 10.1128/JB.00380-18. PMID: 30224439; PMCID: PMC6222196.
Purdy AE. 2018. “Fly models of Vibrio cholerae infection and colonization.” Methods in Molecular Biology, special edition on Vibrio cholerae. Edited by Aleksandra Sikora. Humana Press: New York, NY.
Kamareddine L, ACN Wong, AS Vanhove, S Hang, AE Purdy, K Kierek-Pearson, JM Asara, A Ali, JG Morris Jr., and PI Watnick. 2018. Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host. Nature Microbiology. 3:243-252. doi: 10.1038/s41564-017-0065-7.
Jacob K, A Rasmussen, P Tyler, MM Servos, M Sylla, C Prado, E Daniele, JS Sharp* and AE Purdy*. 2017. Regulation of acetyl-CoA synthetase transcription by the CrbS/R two-component system is conserved in genetically diverse environmental pathogens. PLOS ONE 12(5): e0177825. https://doi.org/10.1371/journal.pone.0177825 *Co-senior authors.
El-Bassoiny G, V Luizzi, D Nguyen, JG Stoffolano Jr. and AE Purdy. 2016. Vibrio cholerae laboratory infection of adult house fly Musca domestica. Medical and Veterinary Entomology 30:392-402.
Hang S, AE Purdy, Z Wang, S Chang, WP Robins, JJ Mekalanos and PI Watnick. 2014. A bacterial acetate switch directs host metabolism from within the intestinal lumen. Cell Host & Microbe 16:592-604. *Highlighed in Nature Reviews Microbiology.
Wang, Z., S. Hang, A. E. Purdy, and P. I. Watnick. 2013. Mutations in the IMD pathway and Mustard counter Vibrio cholerae suppression of intestinal stem cell division in Drosophila. mBio. 4(3) e00337-13.
Purdy, A. E. and P. I. Watnick. 2011. Spatially-selective colonization of the arthropod intestine through activation of Vibrio cholerae biofilm formation. Protocols of the National Academy of Science, USA 108: 19737-19742.
Purdy, A. E., D. Balch, M. L. Lizarraga-Partida, M. S. Islam, J. Martinez-Urtaza, A. Huq, R. R. Colwell, and D. H. Bartlett. 2010. Diversity and distribution of cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae. Environmental Microbiology Reports 2(1): 198–207.
Jorgensen*, R., A. E. Purdy*, R. Fieldhouse, M. Kimber, D. H. Bartlett, and A. R. Merrill. 2008. Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae. Journal of Biological Chemistry 283: 10671-10678. *These authors contributed equally.
Case LK, L Petell, L Yurkovestkiy, A Purdy, KJ Savage and TV Golovkina. 2008. Replication of beta- and gamma- retroviruses is restricted in I/LnJ mice via the same genetic mechanism. Journal of Virology 82:1438-1447.
Makri, S., A. E. Purdy, D. Bartlett, and J. Fierer. 2007. Pathogenicity of environmental isolates of V. cholerae in mice. Microbial Infection 9: 1351-1358.
Purdy, A., F. Rohwer, R. Edwards, F. Azam and D. H. Bartlett. 2005. A glimpse into the genome content of the Vibrio cholerae species through identification of genes present in environmental strains. Journal of Bacteriology 187: 2992-3001.
Valentine, D. L., M. Kastner, G. D. Wardlaw, X. Wang, A. Purdy, and D. H. Bartlett. 2005. Biogeochemical investigations of marine methane seeps, Hydrate Ridge, Oregon. Journal of Geophysical Research, 110, G02005, doi:10.1029/2005JG000025.
Case LK, A Purdy and TV Golovkina. 2005. Molecular and cellular basis for the retrovirus resistance in I/LnJ mice. Journal of Immunology 175:7543-7549.
Purdy A, L Case, M Duvall, M Overstrom-Coleman, N Monnier, A Chervonsky and T Golovkina. 2003. Unique resistance of I/LnJ mice to a retrovirus is due to sustained IFN-g dependent production of virus-neutralizing antibodies. Journal of Experimental Medicine 297:233–243.